Hypertension

Dopamine and metabolite levels similar in three rat strains

Published in Medical Letter on the CDC and FDA, December 28th, 2003

In vivo basal and amphetamine-induced striatal dopamine and metabolite levels are similar in the spontaneously hypertensive, Wistar-Kyoto, and Sprague-Dawley male rats.

According to recent research from the United States, "Nigrostriatal alterations are proposed to partially underlie the hypertension and hyperactivity exhibited by the spontaneously hypertensive rat (SHR). Here, in vivo microdialysis was used to measure baseline and d-amphetamine (AMPH)-stimulated striatal dopamine (DA) and metabolite levels in adult male SHR, Wistar-Kyoto (WKY), and Sprague-Dawley (SD) rats. At approximately 19 weeks of age, baseline levels of DA, 3,4-dihydroxyphenylacetic acid (DOPAC),...

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Source: Medical Letter on the CDC and FDA (2003-12-28)

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