Immunology

CpG oligonucleotides exhibit immunoregulatory activity in humans

Published in Medical Letter on the CDC and FDA, December 28th, 2003

CpG oligonucleotides exhibit immunoregulatory activity in humans and nonhuman primates.

"Oligodeoxynucleotides (ODN) containing CpG motifs mimic the ability of microbial DNA to activate the innate immune system. The resultant response limits the early spread of infectious organisms while promoting the development of adaptive immunity. CpG ODN show promise as vaccine adjuvants and in the treatment of asthma, allergy, infection, and cancer," investigators in the United States report.

"Due to evolutionary divergence in CpG recognition between species, CpG ODN that are most active in rodents are poorly immunostimulatory in primates," said Daniela...

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Source: Medical Letter on the CDC and FDA (2003-12-28)

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