Published in Medical Letter on the CDC and FDA, December 28th, 2003
According to recent research from the United States, "the quantitative adaptation of receptor thresholds allows cells to tailor their responses to changes in ambient ligand concentration in many biological systems. Such a cell-intrinsic calibration of T-cell receptor (TCR) sensitivity could be involved in regulating responses to autoantigens, but this has never been demonstrated for peripheral T cells.
"We examined the ability of monoclonal naive T cells to modulate their responsiveness differentially after exposure to 4-fold different...
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