Anthrax
Calcium may play role in folding pathway of anthrax protective antigen
Published in Medical Letter on the CDC and FDA, January 25th, 2004
"Protective antigen (PA) is the central receptor binding component of anthrax toxin, which translocates catalytic components of the toxin into the cytosol of mammalian cells. Ever since the crystal structure of PA was solved, there have been speculations regarding the possible role of calcium ions present in domain I of the protein," scientists in India report.
"We have carried out a systematic study to elucidate the effect of calcium removal on the structural stability of PA using various optical spectroscopic techniques, limited proteolysis, and mutational analysis,"...
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