Published in Medical Letter on the CDC and FDA, February 8th, 2004
"Bile duct epithelium is physiologically exposed to high concentrations of bile salts, suggesting the presence of a cytoprotective mechanism. The aim of this study was to clarify whether bile salts cause bile duct cell damage and to elucidate the mechanism providing protection against such an action of bile salts. Immortalized mouse cholangiocytes were incubated with taurocholate, taurochenodeoxycholate, glycochenodeoxycholate (GCDC), taurodeoxycholate, and tauroursodeoxycholate (TUDC), followed by flow- cytometric analysis and caspase activity assay to...
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