Hepatitis C Virus

Hepatitis C glycoprotein expression leads to cryptic intron excision

Published in Medical Letter on the CDC and FDA, February 8th, 2004

Expression of unmodified hepatitis C virus envelope glycoprotein-coding sequences leads to cryptic intron excision and cell surface expression of E1/E2 heterodimers comprising full-length and partially deleted E1.

According to published research from the United States, "Hepatitis C virus (HCV) is a positive-strand RNA virus that replicates exclusively in the cytoplasm of infected cells. The viral envelope glycoproteins, E1 and E2, appear to be retained in the endoplasmic reticulum, where viral budding is thought to occur. Surprisingly, we found that the expression system used to generate HCV envelope glycoproteins influences their subcellular localization and...

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Source: Medical Letter on the CDC and FDA (2004-02-08)

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