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Leishmaniasis

 Leishmania lesions affect nasal mucosa in rhesus monkey model

Published in Medical Letter on the CDC and FDA, February 8th, 2004

Scientists describe the Leishmania chronic granulomatous cutaneous lesions that affect the nasal mucosa in a rhesus monkey model.

"The present studies on infections with Leishmania (Viannia) braziliensis in rhesus macaques were made to characterize the evolution of different parasite strains and the immune responses they elicited in this experimental host. A standardized inoculum of promastigotes was injected intradermally either above the eyelid or on the forearm of each monkey. Sixteen infected monkeys developed longstanding infections which lasted until the end of the observation period (33 months)," investigators in Brazil report.

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