Animal Models

Diets with different levels of soy affect toxicity assessments in rats

Published in Medical Letter on the CDC and FDA, February 15th, 2004

Diets with different levels of soy products may affect certain toxicity assessments in female Sprague-Dawley rats.

"Cytochrome P450 1B01 (CYP1B1) has been shown to be important in the bioactivation of 7,12-dimethylbenz[a]anthracene (DMBA) to an adrenal toxin in rats. We investigated the effects of diet and stage of estrous cycle on CYP1B1 expression in rat adrenal glands and on DMBA metabolism by rat adrenal and hepatic microsomes. Female Sprague-Dawley (SD) rats were placed on either standard soy-containing NIH-31 rat chow or soy- and alfalfa-free 5K96 diet from postnatal day (PND) 21 until sacrifice at PND50±5," scientists writing in the journal...

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Source: Medical Letter on the CDC and FDA (2004-02-15)

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