Hydrocephalus
Transgene related to development of congenital hydrocephalus
Published in Medical Letter on the CDC and FDA, February 22nd, 2004
"One line of mice harboring a cardiac-specific epoxygenase transgene developed head swelling and rapid neurological decline in young adulthood, and had marked hydrocephalus of the lateral and third ventricles. The transgene was found to be inserted into an intron in the mouse Rfx4 locus. This insertion apparently prevented expression of a novel variant transcript of RFX4 (RFX4_v3), a member of the regulatory factor X family of winged helix transcription factors," researchers in the United States report.
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