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Medical Letter on the CDC and FDA

Susan Hasty, Publisher

Table of Contents . . . March 14th, 2004

Non-Subscriber - Summaries Only

Related Areas: Other Issues in Medical Letter on the CDC and FDA | Other Publications

Hepatitis E Vaccine - Hepatitis E virus DNA vaccine protected cynomolgus macaques against infection

Poliomyelitis Vaccine - Vaccine-derived polioviruses decline in patients with poliomyelitis

Botulinum Toxin - Mouse bioassay and ELISA compared for detecting botulinum toxin in food

Breast Cancer Risk Factor - Adipose PCB increases risk of breast cancer recurrence in women

Food-borne Illness - Putrescine indicates decomposition in penaeid shrimp

Salmonella - Assay for detecting salmonella in water used for sprout seeds developed

Alcohol Abuse - Five million parents have alcohol problems, federal report says

Amyloidosis - FDA grants fast track approval for Fibrillex

Anesthesia - FDA issues clearance of next generation anesthesia monitor

Anthrax - Surface layer protein EA1 is not component of Bacillus anthracis spores

Avian Influenza - Bird flu not going away soon, WHO says

Avian Influenza - Infection-control company launches fight against avian flu

Avian Influenza - New research could lead to potential treatment for avian flu

Avian Influenza - South Asia health officials hold emergency meeting on avian influenza

Avian Influenza - U.S. senators want task force to deal with avian flu

Avian Influenza - Vaccine could be made quickly if Asian bird flu goes global, U.S. officials say

Bacillus Calmette-Guerin Vaccine - Intranasal BCG vaccine better than subcutaneous vaccine against pulmonary TB

Bovine Spongiform Encephalopathy - Researchers search for new mad cow test

Business & Finance - Trospium maker reports net loss for first quarter 2004

Cancer Therapy - Salvinal has antimitotic activity in drug-resistant human tumor cells

Catheter-Related Infections - U.S. Food and Drug Administration approves clinical trial for MethLock

Childhood Immunization - Parents must get more information to counter immunization fears

Chlamydia - Disease incidence set North Dakota record in 2003

Chronic Beryllium Disease - Electrostatics affect antigen recognition in chronic beryllium disease

Colon Cancer - Gender and location may be related to the pathogenesis of colon cancer

Complementary and Alternative Medicine - FDA approves acupressure wristband for nausea

Complementary and Alternative Medicine - Regulatory issues on safety and efficacy of herbal remedies discussed

Contraception - Bush advocates abstinence-only education

Contraception - FDA postpones morning-after pill decision

Contraception - Survey shows slow start for California's new "pharmacy access" program

Cysticercosis -  Taenia solium antigen diagnostic for cysticercosis characterized

Dengue Fever - Dengue virus strains show promise for candidate vaccines

Dengue Fever - Factors affecting vector competence of dengue virus mosquitoes studied

Dengue Fever - Live-attenuated dengue virus vaccine stimulates TH1 immune responses

Dengue Fever - Safe and immunogenic monovalent attenuated dengue vaccines developed

Dengue Virus - Dengue virus envelope protein changes structure after membrane fusion

Diabetes Management - FDA approves new Guardian Continuous Glucose Monitoring System

Dialysis - FDA clears SpeedLyser infusion catheter

Diet and Nutrition - Breastfeeding longer is beneficial

Disease Prevention - Aging CDC labs will be improved with appropriation of $250 million

Disease Prevention - Federal panel recommends increased mad cow testing

Drug Delivery - ANDA filed for Toprol-XL; generic version of Lotensin launched

Drug Safety - Group joins FDA effort to ensure integrity of drug supply

Ebola Virus - Ebola virus-like particles protect from lethal Ebola virus infection

Ebola Virus - Infection with Ebola virus persists under conditions of partial immunity

Epidemiology - Leukemia panel will meet once more in northern Nevada town

Finance - Diagnostics company reports strong financial results for Q4 and full year 2003

Food-borne Illness -  Yersinia pseudotuberculosis traced to fresh produce for the first time

Food-borne Illness - Effects of handling on biogenic amine formation in fish reported

Generic Drugs - Company announces approval and launch of benazepril hydrochloride tablets

Generic Drugs - FDA approves Benazepril Hydrochloride ANDA

HIV/AIDS Pathogenesis - Immune failure occurs without CD4+ T-cell depletion in SIV-infected macaques

HIV/AIDS Transmission - Heterosexual Hispanics, blacks account for high proportion of cases

HIV/AIDS Treatemnt - Human clinical trials of HIV maturation inhibitor to commence

Heart Disease - FDA requests additional information on decellularized heart valves

Heart Disease Risk - More needs to be done to fight heart disease in young people

Hypertension - Benazepril Hydrochloride Tablets approved for marketing

Hypertension - Company receives final approval on benazepril HCl/HCTZ tablets

Hypertension - FDA plans expedited evaluation of AmVaz NDA

Immunizations - A-Fujian strain tentatively added to influenza vaccine for next year

Immunizations - Campaign launched to immunize against Africa polio outbreak

Immunology - FDA grants orphan drug designation for Altastaph

Infectious Disease - Medical examiner database useful for fatal infectious disease surveillance

Influenza - Flu vaccine's results leave experts uncertain of next season preparations

Influenza - Report finds inactivated influenza virus vaccines effective in children

Influenza - WHO adds Fujian flu to vaccine list for next winter

Influenza Vaccine - Benefit of new influenza vaccine in healthy children investigated

Influenza Vaccine - Signed consent requirement for influenza vaccination should be eliminated

Insomnia - FDA allows IND for extended-release formulation of Sonata

Legal Issues - Federal appeals court upholds dismissal of Zoloft lawsuit

Leukemia - Generic Purinethol tablets receive marketing clearance

Malaria Vaccine - Polymorphism reducing P. falciparum rosetting protects against malaria

Maternal Mortality - WHO: More effort needed to cut the half-million annual deaths in childbirth

Medical Malpractice - U.S. Treasury secretary calls for lawsuit damage cap

Meningitis - Health groups recommend temporary suspension of pediatric vaccine dose

Menopause - FDA approves EstroGel transdermal gel for estrogen therapy

Mergers and Acquisitions - Acquisition gives Nanogen foothold in point-of-care diagnostics market

Mycobacterium - Luminex profiling system applied to M. tuberculosis genotyping

Nutrition - Government computerizes calorie plan

Nutrition - Wild Oats Markets removes all products containing hydrogenated oils

Obstetrics - Number of cesarean deliveries in Pennsylvania continue to rise

Ophthalmic Antibiotic - FDA approves Neomycin, Polymyxin B Sulfates, Bacitracin Zinc ophthalmic ointment

Osteoporosis - Hormone found to protect bones

Pediatric Obesity - National campaign to get kids physically active is working

Peripheral Artery Disease - IND Application filed for peripheral artery disease therapy

Personnel - Mozambique premier to take up research post at U.N. health agency

Presbyopia - FDA panel recommends approval of CK System for near vision improvement

Quality Assurance - Respiratory products manufacturer receives FDA warning letter

Respiratory Medicine - Two formulations of ambroxol hydrochloride tablets are bioequivalent

Smallpox - Few cases of vaccinia transfer reported

Study Ethics - Unusual study tests artificial blood without patients' consent

Systemic Lupus Erythematosus - Enrollment complete in confirmatory phase III clinical trial of Prestara

Tick-borne Encephalitis - Widespread immunization reduces incidence of tick-borne encephalitis

Toxicogenomics - FDA supporting toxicogenomic research through ArrayTrack

Vaccinia Virus - Protein kinase has essential catalytic role in vaccinia virus morphogenesis

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