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Hepatitis E Vaccine

Hepatitis E virus DNA vaccine protected cynomolgus macaques against infection

Published in Medical Letter on the CDC and FDA, March 14th, 2004

A hepatitis E virus DNA vaccine administered by gene gun protected cynomolgus macaques against infection.

According to published research from the United States, "The protective efficacy of a DNA vaccine against hepatitis E virus (HEV) infection was tested in cynomolgus macaques (cynos) vaccinated with a plasmid containing a full-length HEV open-reading frame 2 (ORF2) sequence (Burmese strain) and subsequently challenged with a heterologous strain of HEV (Mexican strain). Cynos administered vaccine by gene gun developed antibodies to HEV (anti-HEV), whereas cynos administered vaccine by intradermal injections and cynos administered a mock DNA construct did not develop...

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