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Breast Cancer Risk Factor

Adipose PCB increases risk of breast cancer recurrence in women

Published in Medical Letter on the CDC and FDA, March 14th, 2004

High levels of polychlorinated biphenyls (PCBs) in adipose tissue increased risk of breast cancer recurrence in women in New York state.

"Several studies have measured the association between blood or adipose concentrations of organochlorinated compounds (OCs), such as pesticides and polychlorinated biphenyls (PCBs), and breast cancer. The estrogenic effects of OCs might adversely affect breast cancer recurrence. The participants were 224 women with nonmetastatic breast cancer enrolled in a New York-based case-control study. Supercritical fluid extraction followed by gas chromatography was conducted on adipose surgical specimens to determine OC concentrations. The mean...

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