Published in Medical Letter on the CDC and FDA, April 25th, 2004
According to a study from the United States, "hCDC4, the gene that encodes the F-box protein responsible for targeting cyclin E for ubiquitin-mediated proteolysis, has been found to be mutated in a number of primary cancers and cancer-derived cell lines. We have observed that functional inactivation of hCDC4 does not necessarily correlate with elevated levels of cyclin E in tumors. Here we show, however, that hCDC4 mutation in primary tumors correlates strongly with loss of cell cycle regulation of cyclin E."
"Similarly, a breast carcinoma-derived cell line mutated for hCDC4...
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