Hepatitis C Vaccine

Envelope protein-based vaccine enhances delays hepatitis C virus infection

Published in Medical Letter on the CDC and FDA, May 2nd, 2004

Immunization of chimpanzees with an envelope protein-based vaccine enhances specific humoral and cellular immune responses that delay hepatitis C virus infection.

"Two chimpanzees, one naive (Ch1601) and one recovered from hepatitis C virus (HCV) acute infection (Ch1587), were vaccinated with recombinant envelope glycoproteins (E1E2) and then challenged with 100 CID₅₀ of HCV. Results of the challenge were compared to infection in a non-vaccinated control animal. Immunization generated high antibody titers to E1E2 including antibody specifically directed to the hypervariable region 1 (HVR1) in addition to strong and specific HVR1 T-cell proliferative...

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Source: Medical Letter on the CDC and FDA (2004-05-02)

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