Malaria

Co-ligand complex anchors malaria merozoites to erythrocyte invasion receptor

Published in Medical Letter on the CDC and FDA, May 2nd, 2004

A co-ligand complex anchors Plasmodium falciparum merozoites to the erythrocyte invasion receptor band 3.

"In Plasmodium falciparum malaria, erythrocyte invasion by circulating merozoites may occur via two distinct pathways involving either a sialic acid-dependent or -independent mechanism. Earlier, we identified two nonglycosylated exofacial regions of erythrocyte band 3 termed 5ABC and 6A as an important host receptor in the sialic acid-independent invasion pathway. 5ABC, a major segment of this receptor, interacts with the 42-kDa processing product of merozoite surface protein 1 (MSP1₄₂ ) through its 19-kDa C-terminal domain," scientists in...

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Source: Medical Letter on the CDC and FDA (2004-05-02)

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