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Occupational Health

GC method for quantifying 3-bromopropionic acid in urine developed

Published in Medical Letter on the CDC and FDA, May 9th, 2004

Scientists have developed a gas chromatographic method for the quantification of the biomarker 3-bromopropionic acid in human urine.

"An accurate and precise method was developed for the detection and quantification of 3-bromopropionic acid (3-BPA), a metabolite and biomarker for exposure to 1-bromopropane (1-BP). 1-BP is used as an industrial solvent and exposure is a health concern for industrial workers due to its toxicity. It has been associated with neurological disorders in both animals and humans," investigators in the United States report.

"Urine sample preparation for the determination of 3-BPA consisted of liquid-liquid extraction (LLE)...

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