Malaria Vaccine
Disulfide bonds in malaria surface protein impede antigen processing
Published in Medical Letter on the CDC and FDA, May 16th, 2004
According to recent research from the U.K., "The 19-kDa C-terminal fragment of the malaria parasite merozoite surface protein 1 (MSP119 ) is a leading malaria vaccine candidate. In rodents, high antibody levels to this protein confer protective immunity, and can be generated by immunization with the antigen in adjuvants. In natural human infections, however, MSP119 -specific antibody responses can be short-lived and comparatively low, despite repeated exposure to infection.
"The...
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