Prion Disease
Variations in infectious protein determine prion strain differences
Published in Medical Letter on the CDC and FDA, May 16th, 2004
According to a study from the United States, "A remarkable feature of prion biology is the strain phenomenon wherein prion particles apparently composed of the same protein lead to phenotypically distinct transmissible states. To reconcile the existence of strains with the 'protein-only' hypothesis of prion transmission, it has been proposed that a single protein can misfold into multiple distinct infectious forms, one for each different strain.
"Several studies have found correlations between strain phenotypes and conformations of prion particles; however, whether...
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