Susan Hasty, Publisher
Table of Contents . . . May 30th, 2004
Non-Subscriber - Summaries OnlyRelated Areas: Other Issues in Medical Letter on the CDC and FDA | Other Publications
Anthrax - Anthrax lethal toxin neutralization assay validated
DNA Microarray - Correction for dye-bias in microarray gene expression studies reported
Hormone Replacement Therapy - Postmenopausal estrogen guidelines for treating hot flashes released
Lead Poisoning - Lead-contaminated moonshine constitutes significant health hazard
Mycobacterium - M. tuberculosis strain with resistance to isoniazid identified
AIDS/HIV Therapy - Lymphocytes in transgenic mice are resistant to viral infection
AIDS/HIV Transmission - AZT causes pattern of mutations in Tk gene of mice treated as neonates
AIDS/HIV Vaccine - Immune efficiency correlates with specific targeting
Allergy Therapy - FDA approves chewable allergy medicine for children
Alzheimer Disease - Progress being made toward structural understanding of amyloid fibrils
Alzheimer Disease Therapy - Memantine (Namenda) approved for moderate to severe Alzheimer disease
Anthrax - Anthrax lethal factor-cleavage products of MAPK exhibit reduced binding
Anthrax Vaccine - Glycine prevents thermal inactivation of Bacillus anthracis antigen
Antibiotic Resistance - Pediatrician approach can influence parental agreement with treatment
Arrhythmia - FDA clears steerable cardiac catheters
Assisted Reproduction - Worldwide distribution agreements signed for Cumulase
Asthma - FDA approval granted for Theophylline
Attention Deficit Hyperactivity Disorder - FDA issues approvable letter for Concerta 72 mg
Benign Prostatic Hyperplasia - FDA approves Proscar combined with Doxazosin
Bioterrorism - Bioterrorism fear may cause mass sociogenic illness
Blood Banking - Galileo cleared by U.S. Food and Drug Administration for use in U.S.
Breast Cancer - FDA issues 510k clearance for single-channel device for HDR brachytherapy
Cancer Risk Factor - Nitrites consumed from animal products may increase pancreatic cancer risk
Cancer Vaccine - Immunoregulatory T cells in tumor immunity reviewed
Candidiasis - Company submits NDA for treatment of esophageal candidiasis
Cardiology - Diastolic Ca2+ release controls beat rate of rabbit sinoatrial node cells
Cardiology - Membrane depolarization not needed for diastolic RyR Ca2+ release
Cataract - FDA approves new labeling claims for lens implant
Childhood Immunization - Business strategy used to increase vaccination rates in children
Chronic Pain - FDA approves rechargeable implantable spinal cord stimulation system
Clinical Trials - Cancer therapeutics company names Jerry McMahon CEO; Jack Bowman to retire
Collaborations - Ortec to collaborate to facilitate stem-cell therapy development
Compliance - Report: Many healthcare organizations remain noncompliant with HIPAA
Critical Care Medicine - Discharge diagnoses not suitable for monitoring surgical infections
Cystic Fibrosis - Company announces positive results in cystic fibrosis study
Cystic Fibrosis Therapy - FDA mandates approval for all pancreatic enzyme replacement products
Cytotoxicity - Copper counteracts the toxic effects selenite has on human cancer cells
Dementia - Portraits of dignity in dementia presented
Drug Delivery - Positive results reported on CAP adjuvant study in CDC collaboration
Drug Delivery - Research: ZOMIG nasal spray single dose is rapidly absorbed intranasally
Drug Resistance - Extended-spectrum beta-lactamase-producing bacteria risks outlined
Emergency Contraception - FDA turns down OTC Plan B; outlines necessary information for approval
Emergency Contraception - Medical groups urge FDA not to delay OTC status to EC pill
Endoscopic Products - Flexible Cystoscope with Slide-On EndoSheath System receives FDA clearance
Enterococcus - Three new enterococcal species from human specimens characterized
Environmental Health - Mutations in Big Blue rats fed leucomalachite green analyzed
Environmental Toxins - New research outlines public health consequences of 911 rescue efforts
Epidemiology - Computers combat disease: new modeling grants target epidemics, bioterror
Epidemiology - Prevalence of HIV among childbearing women has declined in New York
Facial Wrinkles - FDA approves Hylaform gel for the correction of facial wrinkles
Finance - Albuferon maker reports increased net losses, mostly due to R&D
Finance - Genasense maker reports first quarter revenues of $1.7 million
Finance - Spinal device company reports 77% increase in net sales during first quarter
Food-Borne Illness - FDA announces modernization of food good manufacturing practices
Gastric Ulcers - FDA accepts NDA for Rapinex powder for oral suspension 40mg
Generic Drugs - Innovative acquires abbreviated new drug application for Cephalexin
Glucose Control - FDA approval granted for Fortamet; Altocor gets new name
HIV/AIDS - SBIR grant to fund company's HIV/AIDS program
HIV/AIDS Treatment - South Africa's government faulted for surging AIDS deaths
Hantavirus - Wounding is primary mode of Seoul virus transmission in male rats
Heart Failure Therapy - Valsartan offers benefits for treatment of heart failure
Hemorrhagic Fever - Bovine aortic endothelial cells susceptible to Hantaan virus infection
Hypertension - FDA grants orphan drug status to Hydralazine
Hypertension - Ranbaxy receives approval to market fosinopril sodium tablets
Immunology - Allergy and immunology organization wins $25 million contract from NIH
Immunology - T-cell sphingosine 1-phosphate receptor regulates thymic egress
Infant Mortality - Breastfeeding decreases risk of infant death in the U.S.
Influenza - Immunization practices group recommends flu vaccine for young children
Injury Prevention - Child safety restraint use increasing in auto trips
Leishmaniasis - Leishmanial amastigote antigen induces natural killer-cell reactivity
Leishmaniasis Vaccine - Vaccine confers resistance to Leishmania donovani in mice
Leukemia - FDA approves Cladribine injection for hairy cell leukemia
Macular Degeneration - SnET2 trial shows promise for AMD
Malaria - Benin gets mosquito nets to protect children, pregnant women
Mental Health - Psychotropic drug interactions reviewed
Metabolic Syndrome - Scientists push forward understanding of "epidemic" diseases
Microencapsulation - All-trans-retinoic acid release nanoparticles reported
Minority Health - Latino/Hispanic diabetes media awareness campaign described
Mosquito-Borne Disease - Devices for monitoring Aedes aegypti in Peru evaluated
Mosquito-Borne Disease - Rainfall and evapotranspiration effects on Anopheles dynamics reported
Neoplasm Therapy - MTH-68/H oncolytic viral treatment promising for high-grade gliomas
Neurotoxin - Electroencephalographic and c-fos responses to dombic acid reported
Nicotine Addiction - Exotic cigarettes popular with minority youth
Nutrition - Group urges FDA to reconsider fat disqualifying level for health claims
Obstetrics - Success in assisted reproduction may be singleton live birth rate
Parkinson Disease - Study suggests levetiracetam may benefit patients with Parkinson disease
Peripheral Vascular Disease - FDA approves laser technology for total occlusions in leg arteries
Pertussis - Levels of pertussis subunits and Ptl proteins in B. pertussis reported
Prostate Cancer - Focus signs agreement with USHIFU to fund prostate cancer clinical trials
Rotavirus - NIAID rotavirus vaccine licensed for commercialization
Rotavirus - NIH attempts to revive controversial rotavirus vaccine
Saccharomyces - Bbp1p required for mitotic functions of Cdc5p in Saccharomyces
Spina Bifida - CDC report compares birth defect rates before and after folic acid mandate
Stroke - Too few Americans aware of stroke warning signs
Trypanosomiasis - FDA grants fast track designation to DB289, for African sleeping sickness
Varicella Vaccine - Two cases of congenital varicella syndrome reported
Ventricular Assist Devices - NIH awards contract to develop heart pump for children
Ventricular Assist Devices - NIH awards contract to develop implantable blood pump for babies
Visual Acuity - FACT tests yield different results due to features affecting viewing
West Nile Fever - West Nile virus present in Guadeloupe animals
Whooping Cough - Pertussis vaccination program may be cost-effective in face of rising incidence
Zoonoses - Only some Enterocytozoon bieneusi isolates have zoonotic potential
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