Anthrax

Anthrax lethal factor-cleavage products of MAPK exhibit reduced binding

Published in Medical Letter on the CDC and FDA, May 30th, 2004

Anthrax lethal factor-cleavage products of mitogen-activated protein kinase (MAPK) kinases exhibit reduced binding to their cognate MAPKs.

According to published research from the United States, "Anthrax lethal toxin is the major cause of death in systemic anthrax. Lethal toxin consists of two proteins: protective antigen and LF (lethal factor). Protective antigen binds to a cell-surface receptor and transports LF into the cytosol.

"LF is a metalloprotease that targets MKKs [MAPK (mitogen-activated protein kinase) kinases]/MEKs [MAPK/ERK (extracellular-signal-regulated kinase) kinases], cleaving them to remove a small N-terminal stretch but leaving...

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Source: Medical Letter on the CDC and FDA (2004-05-30)

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