Cardiology
Diastolic Ca2+ release controls beat rate of rabbit sinoatrial node cells
Published in Medical Letter on the CDC and FDA, May 30th, 2004
"Recent studies employing Ca2+ indicators and confocal microscopy demonstrate substantial local Ca2+ release beneath the cell plasma membrane (subspace) of sinoatrial node cells (SANCs) occurring during diastolic depolarization," scientists in the United States explained.
"Pharmacological and biophysical experiments have suggested that the released Ca2+ interacts with the plasma membrane via the ion current (INaCa ) produced by the Na+/Ca2+ exchanger and constitutes an important determinant of...
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