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Rotavirus

NIH attempts to revive controversial rotavirus vaccine

Published in Medical Letter on the CDC and FDA, May 30th, 2004

The U.S. National Institutes of Health (NIH) is attempting to revive an anti-diarrhea vaccine that was pulled off the market 5 years ago after a life-threatening side effect struck some babies.

At issue is rotavirus, an intestinal infection that kills 600,000 children worldwide each year. In the United States, 3 million children get rotavirus annually, but good medical care ensures only about 40 of them die. In developing countries, however, about one child in every 250 dies of rotavirus.

The first vaccine, called RotaShield, was pulled off the market by its manufacturer in 1999 after 20 U.S. infants, of the almost 1 million vaccinated, suffered a...

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