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Medical Letter on the CDC and FDA

Susan Hasty, Publisher

Table of Contents . . . June 6th, 2004

Non-Subscriber - Summaries Only

Related Areas: Other Issues in Medical Letter on the CDC and FDA | Other Publications

Charcot-Marie-Tooth Disease - Ascorbic acid corrects phenotype of Charcot-Marie-Tooth disease

Hepatitis - Molecular epidemiology of hepatitis B and C infections in Asia reviewed

Hepatology - Chronic liver disease mortality in the United States reported

Influenza - Pandemic influenza can be contained with antiviral agents

Malaria Transmission - Isonicotinic acid hydrazide inhibits malaria transmission in mosquito

AIDS/HIV Genomics and Genetics - Wild-type CCR5 confers HIV-1 cross-clade resistance

AIDS/HIV Transmission - Maternal malaria and perinatal HIV transmission interaction complicated

AIDS/HIV Vaccine - Components of HIV vaccine are recognized by T-helper cells

AIDS/HIV Vaccine - IL-15 may be beneficial for AIDS immunotherapy

AIDS/HIV Vaccine - Virus-like particles rich in HIV-1 envelope gp120 developed

Allergy Medicine - Mice exposed to formaldehyde exhibit different inflammatory responses

Animal Models - Animal studies used to determine risks of environmental toxicants

Animal Research - Northwestern records on animal research inquiry subpoenaed by U.S. government

Anthrax Vaccine - Membranal polypeptides of Bacillus anthracis identified

Antibiotics - Novel inhibitors of bacterial RNA polymerase I characterized

Ataxia-Telangiectasia - Antioxidant corrects neurobehavioral defect in ataxia-telangiectasia

Avian Influenza - Avian influenza may be new pandemic threat

Benign Prostatic Hyperplasia - New FDA-approved catheter designed to treat shorter prostate lengths in BPH

Bubonic Plague - Flea-borne transmission model evaluates vaccines against bubonic plague

Business Update - Company submits IND to the FDA for ALS; announces the resignation of CEO

Cervical Cancer - WHO agency confirms efficacy of screening women 25-65 to reduce mortality

Chlamydia - Incidence of chlamydial infection at all-time high in Washington state

Chlamydia - Prevalence of chlamydial infection high among young adults in U.S.

Colon Cancer - Company launches colon cancer trial with GTI-2040

Complementary and Alternative Medicine - Levels of aristolochic acids in Chinese herbs determined by NMR

DNA Research - 4-methylthio-1-butyl group protects phosphate/thiophosphate groups

Diabetes Pathogenesis - PPAR-alpha deficiency does not alter insulin sensitivity in mice

Diet and Nutrition - Reference materials program for dietary supplements outlined

Drug Delivery - FDA approves Vitrase for use as a spreading agent

Emergency Contraception - Ob/gyn group issues statement on FDA's non-approval of OTC status for Plan B

Environmental Health - CYP1A2 is not required for dioxin-induced immunosuppression

Environmental Health - Developmental pharmacology principles applied to environmental toxins

Environmental Health - Mercury exposure and child development outcomes reviewed

Environmental Health - Vaccine-derived poliovirus isolated from stream waters in Hispaniola

Finance - Affinitak maker reports decrease in revenues during first quarter

Finance - CardioSEAL maker announces increased first quarter revenue

Food-Borne Illness - Arsenic determined in infant food products by IC-ICP-MS

Food-Borne Illness - Gene probes for quantifying Vibrio in crabmeat evaluated

Generic Drugs - Company receives first-to-file status on gabapentin tablets

HIV/AIDS Prevention - Experts say hunger and AIDS create vicious cycle in Africa

Healthcare Access - WHO: More AIDS clinics needed in countries

Healthcare Costs - HMS teams with MDwise to coordinate benefits for Medicaid managed care

Heart Disease Risk Factor - Role of noninvasive studies in risk for sudden cardiac death reviewed

Hemorrhagic Fever - Crimean-Congo hemorrhagic fever virus genome L RNA segment sequenced

Hepatitis - Site provides information about hepatitis infection and therapy

Hepatitis C Epidemiology - Risk factors for hepatitis C in Alaska natives reported

Hepatitis C Therapy - Immune responses in patients with hepatitis C and HIV described

Hepatitis Vaccine - Hepatitis A/B vaccine cost-effective substitute for hepatitis B vaccine

Hepatitis Vaccine - Hepatitis vaccination in patients with chronic liver disease reviewed

Herpesvirus - Human herpesvirus-8 oral shedding higher without antiretroviral therapy

Hypertension - NDA submitted for nebivolol

Immunotherapy - CpG oligodeoxynucleotides find immunotherapeutic use

Legal Issues - Annan to contact Libyan government over death sentences for six health workers

Legal Issues - Libyan protesters burn American flag to denounce U.S. criticism of AIDS trial

Leishmaniasis - Cross-talk between CD8+ and CD4+ T cells occurs in leishmaniasis

Leishmaniasis - Leishmaniasis in Brazil is a disease of urban-rural interface

Liver Cancer Risk Factor - Most hepatocellular carcinoma in West Africa caused by hepatitis B

Malaria - Circumsporozoite antigens quantified in Plasmodium-infected mosquitoes

Malaria - Malaria sporozoites infect cells by two pathways

Malaria - Rare mutation in gene of P. falciparum isolates identified

Malaria Genomics and Genetics - Genotypes of malaria-infected patients in Papua New Guinea reported

Malaria Vaccine -  Plasmodium falciparum peptides bind to human hepatocytes

Malaria Vaccine -  Plasmodium gametocyte stages neglected in vaccine development

Malaria Vaccine - Displacement in 6725 SERA peptide analogue protects against malaria

Malaria Vaccine - Malaria vaccine results indicate protection related to antibody levels

Malaria Vaccine - Response to conserved epitope linked to protection from malaria

Malaria Vaccine - Vaccine genes of P. falciparum during hepatic phase identified

Malaria Vaccine - X-ray analysis conducted on protein vaccine candidate for malaria

Measles Vaccine - Aerosol better than subcutaneous delivery for measles booster

Metapneumovirus - Human metapneumovirus infection similar in severity to RSV in children

Ophthalmology - Presence of certain eye disorders linked with poorer survival rates

Pain Therapy - Animal studies show promise treating severe chronic pain

Pancreatic Cancer - No link found between IGF or IGF-binding protein and pancreatic cancer

Pneumococcal Disease - Predictors of pneumococcal carriage and resistance in children reported

Pneumococcal Disease - Vaccine reduces racial disparity in incidence of childhood pneumonia, meningitis

Pneumococcal Vaccine - Two pneumococcal vaccines safe and effective in American Indian infants

Political Conflict - Women suffering brunt of conflict in Western Sudan, UNFPA warns

Proteomics - Model to assess risk of non-ionizing pulsed radiation developed

Proteomics - Protein folding 'speed limit' estimated

Public Health - Cost analysis of bike and pedestrian trails outlined

Public Health - Methods for ranking cities by public health criteria reported

River Blindness - Studies show success of Mectizan partnerships

Rubella Epidemiology - Rubella in developing countries still causing blindness and deafness

SARS Vaccine - DNA vaccine induces SARS coronavirus protective immunity in mice

SARS Vaccine - Passive transfer of antibody prevents SARS replication

Sexual And Reproductive Health - FDA issues not approvable letter for OTC "morning after" pill

Smallpox - Imvamune smallpox vaccine clinical study to include eczema patients

Smallpox - Third-generation vaccine against smallpox tested

Smallpox Vaccine - Method developed to monitor immune response against vaccinia virus

Smallpox Vaccine - Prevalence of dermatologic reactions to smallpox vaccine reported

Solid Cancer - Advances in molecular carcinogenesis reviewed

Sudden Cardiac Death - Researcher finds genetic explanations for some previously unexplained deaths

Technology - New modeling grants target epidemics, bioterror

Toxicology - Fate of chemicals in skin after dermal application investigated

Tumor Suppressor Gene - Large intestinal tumors induced by o-Nitrotoluene in B6C3F1 mouse model

Typhoid Fever - Method to diagnose typhoid fever using antigens in urine developed

Vaccine Safety - MMR vaccine controversy offers insights into health risk communication

Vectors and Zoonoses - Simple assay developed to assess feeding habits of Meprai spinolai

Violence - Higher rates of trauma increase urban American Indian women's risk for HIV

Yellow Fever Virus - Wild-type yellow fever virus linked to 17DD vaccine characterized

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