AIDS/HIV Vaccine
Virus-like particles rich in HIV-1 envelope gp120 developed
Published in Medical Letter on the CDC and FDA, June 6th, 2004
"In order to improve the immunogenicity of HIV-1 envelope glycoproteins, we have fused gp120 to a carrier protein, hepatitis B surface antigen (HBsAg), which is capable of spontaneous assembly into virus-like particles. The HBsAg-gp120 hybrid proteins assembled efficiently into 20-30 nm particles. The particles resemble native HBsAg particles in size and density, consistent with a lipid composition of about 25% and a gp120 content of about 100 per particle," researchers in the United States report.
"Particulate gp120 folds in its native conformation and is biologically...
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