Antibiotics
Novel inhibitors of bacterial RNA polymerase I characterized
Published in Medical Letter on the CDC and FDA, June 6th, 2004
According to recent research from Italy, "GE 23077 factors A1, A2, B1, and B2 are novel antibiotics isolated from fermentation broths of an Actinomadura species strain. GE23077 antibiotics are cyclic peptides, which inhibit Escherichia coli RNA polymerase at nM concentrations.
"Both rifampicin-sensitive and rifampicin-resistant polymerases are inhibited, whereas E. coli DNA polymerase and wheat germ RNA polymerase are substantially not affected," reported Ismaela Ciciliato and colleagues at Vicuron Pharmaceuticals. "In spite of the potent activity on...
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