AIDS/HIV Therapy
Nucleoside analogues and mitochondrial toxicity reviewed
Published in Medical Letter on the CDC and FDA, June 13th, 2004
"An evaluation of the U.S. Food and Drug Administration's Adverse Event Reporting System identified that patients co-infected with human immunodeficiency virus and chronic hepatitis C virus who were treated with a regimen of ribavirin and didanosine, with or without stavudine, were at increased risk for events associated with mitochondrial toxicity, including fatal hepatic failure, peripheral neuropathy, pancreatitis, and symptomatic hyperlactatemia/lactic acidosis," investigators in the United States report.
"In response, the...
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