Oncogenesis
CDC91L1 is newly discovered oncogene in human bladder cancer
Published in Medical Letter on the CDC and FDA, June 13th, 2004
"Genomic amplification at 20q11-13 is a common event in human cancers. We isolated a germline translocation breakpoint at 20q11 from a bladder cancer patient. We identified CDC91L1, the gene encoding CDC91L1 (also called phosphatidylinositol glycan class U (PIG-U), a transamidase complex unit in the glycosylphosphatidylinositol (GPI) anchoring pathway), as the only gene whose expression was affected by the translocation," investigators in the United States report.
"CDC91L1 was amplified and overexpressed in about one-third of bladder cancer cell lines and primary tumors, as well...
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