Hepatitis B Virus

Spread of hepatitis B viruses in vitro requires extracellular progeny

Published in Medical Letter on the CDC and FDA, June 20th, 2004

The spread of hepatitis B viruses in vitro requires extracellular progeny and may be codetermined by polarized egress.

According to recent research published in the Journal of Virology, "Viruses can spread by different mechanisms: via intracellular particles through cell junctions to neighboring cells or via secreted virions to adjacent or remote cells. The observation of clusters of hepadnavirus-infected cells both in vivo and in primary hepatocytes neither proves the first mechanism nor excludes the second. In order to test which mechanism, if not both, is used by hepatitis B viruses in order to spread, we used primary duck hepatocytes and duck hepatitis B...

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Source: Medical Letter on the CDC and FDA (2004-06-20)

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