Crohn Disease
Guts get a NOD
Published in Medical Letter on the CDC and FDA, July 18th, 2004
In the August 2004 issue of Nature Immunology Warren Strober and colleagues at the National Institute of Allergy and Infectious Disease, part of the U.S. National Institutes of Health, have discovered how these alterations can cause bowel disease.
Toll-like receptors (TLRs) on the surface of gut cells alert the host to the presence of pathogenic bacteria and initiate inflammation. Strober and colleagues examined a model for human CD: mice deficient in NOD2. They found that NOD2...
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