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Respiratory Syncytial Virus

Pulmonary delivery of RSV vaccines achieved via albumin particles

Published in Medical Letter on the CDC and FDA, August 22nd, 2004

Pulmonary delivery of respiratory syncytial virus DNA vaccines is achieved using macroaggregated albumin particles.

"At present there is no safe and effective vaccine for respiratory syncytial virus (RSV). DNA vaccines encoding RSV surface glycoproteins are one option being examined. Current methods to deliver DNA vaccines generally require repeated high dose intramuscular or intradermal administration for effectiveness. In this study, we examine the efficacy of pulmonary DNA vaccination using low dose DNA vaccines encoding the RSV F glycoprotein conjugated to macroaggregated albumin (MAA-F)," scientists in the United States report.

"Single...

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