Cancer Vaccine

Irradiation of tumors promotes vaccine-mediated T-cell killing

Published in Medical Letter on the CDC and FDA, August 29th, 2004

External beam irradiation of tumors alters phenotype of tumor cells to render them susceptible to vaccine-mediated T-cell killing.

According to a study from the United States, "Local radiation is an established therapy for human tumors. Radiation also has been shown to alter the phenotype of target tissue, including gene products that may make tumor cells more susceptible to T-cell-mediated immune attack. We demonstrate a biological synergy between local radiation of tumor and active vaccine therapy. The model used consisted of mice transgenic for human carcinoembryonic antigen (CEA) and a murine carcinoma cell line transfected with CEA."

"The...

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Source: Medical Letter on the CDC and FDA (2004-08-29)

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