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Table of Contents . . . September 5th, 2004
Non-Subscriber - Summaries Only
Related Areas: Other Issues in Medical Letter on the CDC & FDA | Other Publications
Alcoholism - Mass media campaigns effective for reducing alcohol-involved crashes
Diabetes Survival & Mortality - Diabetes increases cancer mortality risk for some cancer types
Food-Borne Illness - Antimicrobial drug delivery in food animals reviewed
HIV/AIDS Epidemiology - American Indians and Alaska natives surveilled for HIV/AIDS and risk behaviors
Malaria - Retrospective of re-infection of humans with Plasmodium published
AIDS/HIV Pathogenesis - Malnutrition increases risk of acquired immunodeficiency syndrome
AIDS/HIV Vaccine - DNA prime-MVA boost HIV vaccine tailored for eastern and central Africa
Addiction Medicine - Buprenorphine for treatment of opiate dependence reviewed
Addiction Medicine - FDA approves Campral Delayed-Release Tablets for treating alcohol dependence
Allergy Medicine - Quaternary ammonium compounds exhibit adjuvant effect in murine model
Alzheimer Disease - Transgenic animal models of Alzheimer disease reviewed
Angina - Trial of Ranexa initiated for certain patients with chronic angina
Angiology - Inflammatory cytokines referee angiogenic control during inflammation
Antioxidants - Induction of metallothionein requires transcription factor and zinc
Avian Influenza - Scientists warn about pandemic potential of lesser-known bird flu strain
Bioterrorism - Nebraska proposes 10-state bioterrorism alliance
Blood Donations - Company introduces enhanced red cell collection technology
Botulinum Toxin - Novel method developed to quantify botulinum neurotoxin antibodies
Breast Cancer - Orphan drug designation granted from U.S. FDA for Efaproxyn
Breast Implants - 7-year deflation rate data filed for breast implants post approval survey study
Breastfeeding - Public beliefs about breastfeeding policies in various settings
Business & Finance - Company reports $8.8M Q2 loss, provides clinical update
Business Update - Generics producer granted rights for fluconazole, intends to file antiretroviral
Cancer Therapy - Antibody-targeted radiation cancer therapy reviewed
Cancer Vaccine - Mesothelin is new target for immunotherapy of mesotheliomas
Cancer Vaccine - Viral chemokine fusions trigger antitumor immunity independent of chemotaxis
Cardiovascular Disease - FDA approves Lipitor to lower risk of heart attacks
Cardiovascular Disease - Pre-IND meeting held with FDA for platelet aggregation inhibitor
Chickenpox - Varicella vaccine reduces contagiousness of chickenpox
Cholera Vaccine - V. cholerae polysaccharide fragments are immunogenic in mice
Colon Cancer - Clinic's participation in colon cancer drug study provides access to new therapy
Depression - FDA approves Cymbalta for the treatment of depression
Depression - Physician notification program launched for kids on antidepressants
Diabetes Epidemiology - Millions of American Indians, Alaska Natives at risk for type 2 diabetes
Diagnostics - Company launches FDA-cleared high sensitivity Troponin I assay
Diagnostics - FDA provides clearance for MAGNETOM C!
Diagnostics - Monocyte activation test for parenteral drug contaminants developed
Diagnostics - U.S. FDA clearance given for herpes simplex virus assay
Diet and Nutrition - Mothers misunderstand questions on feeding questionnaire
Drug Development - Biopharmaceutical company initiates clinical trial of TRX4 for psoriasis
Drug Development - Orphan drug designation granted for key component in liver assist program
Drug Development - U.S. FDA approves new drug application for generic topical cortisone ointment
Drug Development - U.S. FDA grants orphan drug designation for pulmonary arterial hypertension drug
Drug Security - Drug companies approach brand security issue head on, study shows
Ebola - WHO announces end of Ebola outbreak in southern Sudan
Endocrine Disorders - Methylprednisolone Sodium Succinate approved by FDA
Environmental Health - EPA orders end to 'wet method' asbestos removal at airport project
Environmental Toxins - Disagreements over fluoridation of public water still strong after 50 years
Environmental Toxins - Tobacco industry attempted to influence reporting on secondhand smoke
Fetal Alcohol Syndrome - New hope for children with fetal alcohol syndrome
Finance - Oncology-focused biopharma reports record product revenues Q2 2004
Finance - Pharmaceutical company reports second quarter results
Funding - Tuberculosis prevalence rates in China fall after DOTS introduced by WHO
Genetic Abnormalities - Ariol 2.0 launched as next-generation cellular imaging system
Genomics - Scientists announce breakthrough in pathway engineering
Geriatrics - Study examines inappropriate medication prescribing for elderly patients
Glaucoma - Approvable letter issued by FDA for Lumigan
HIV/AIDS Coinfection - HSV-2 infection increases risk of HIV transmission
HIV/AIDS Epidemiology - Condom use reduces rate of new HIV infections in Thailand
HIV/AIDS Prevention - HIV prevention drug gets U.S. FDA clearance to advance in phase 1 clinical trial
HIV/AIDS Research - Noninfectious X4 but not R5 HIV-1 inhibits lymphoid tissue antibody response
HIV/AIDS Treatment - Comprehensive strategy needed to access antiretroviral treatment in South Africa
HIV/AIDS Treatment - FDA approves Sculptra (injectable poly-L-lactic acid)
HIV/AIDS Treatment - FDA approves two fixed-dose combination drug products for HIV-1 infection
HIV/AIDS Treatment - U.S. FDA approves Truvada as part of HIV combination therapy
HIV/AIDS Treatment - US$5-6 billion needed by 2005 to provide ART to low-, middle-income countries
Healthcare Coverage - GLIADEL Wafer assigned new DRG designation
Healthcare Funding - Japan gives Cambodia nearly US$25 million for healthcare
Hepatitis Epidemiology - Seroprevalence of markers of viral hepatitis in Yemeni healthcare workers
Hypogonadism - Trial finds effective treatment for testosterone replacement
Illicit Drugs - Feds say "club drug"-related visits to ERs show some sharp declines
Immunology - VIG product submitted for FDA approval
Immunotherapy - Human B cells are alternative source of efficient antigen-presenting cells
Infection Control - Day of week and collection length vital to nosocomial infection surveys
Infectious Disease - Rodent prey reduce reservoirs of transmissible pathogens
Influenza - CDC: Flu shot effective more than half of the time
Influenza - Company delivers first million doses of Fluvirin vaccine to U.S. distributors
Influenza - First influenza vaccine shipped to healthcare providers
Influenza - Influenza causes excess hospital admissions in Hong Kong
Injury Prevention - CDC: Animals cause more than 26,000 roadway injuries each year
Leishmaniasis - Action in Afghanistan aims to control debilitating disease
Leukemia - Cell loading system used in phase I/II gene therapy trial for leukemia
Lyme Disease Vaccine - Lyme borreliosis from infection to autoimmunity reviewed
Malaria - Fever temperature linked to malaria infectivity rate
Market Analysis - Forecasting company predicts anticholesterol market share for Vytorin
Measles - CDC: Measles cases lowest since 1912
Medical Devices - Company begins human clinical trial in age related macular degeneration
Medical Devices - Heart device maker comments on CMS VAD reimbursement notice in Federal Register
Medical Devices - New laser eye surgery policies established by U.S. veteran's agency
Medical Devices - Piezoelectric transducers used for low-frequency calibration of hydrophones
Medical Equipment - U.S. FDA 510(k) clears new dose calculator for radiotherapy treatment plans
Neuroscience - Transgenic mice show Notch signaling is important for synaptic plasticity
Non-Small Cell Lung Cancer - Genentech and partner announce NDA completion for Tarceva
Nutrition - Panel advises more vegetable consumption
Obesity Prevention - National report card shows states "failing" to check obesity
Obesity and Diabetes - Metabolic syndrome treatment strategies outlined
Ophthalmology - Latinos have high levels of visual impairment and eye disease
Ophthalmology - Squalamine stems the growth of new blood vessels in mice with retinopathy
Oral Cancer - Oral cancer epidemic expected due to use of betel quid substitutes
Ovarian Cancer - Sensitivity, specificity of MS-obtained proteomic diagnostic patterns compared
Pain Medicine - NSAIDs increase expression of cyclooxygenase in inflamed spinal cords
Pain Treatment - New guidelines set for better pain treatment
Parasitic Disease - Rapid response should bring parasitic epidemic in Afghanistan under control
Peptic Ulcers - FDA clears POCone Infrared Spectrophotometer
Policy - Government decides not to intervene and force down AIDS drug price
Prescription Drugs - U.S. customs seizes prescription drug shipment in Miami
Prion Disease - Bovine normal prion protein PrP(104-242) purified by HPHIC
Product Licensing - Specialty drug company receives U.S. FDA approval for mint flavor nicotine gum
Prostate Cancer - Biopharmaceutical company provides update on DN-101 Plus Taxotere trial
Psoriasis - Phase I trial results reported for Psoraxine
Psoriatic Arthritis - E.U. CHMP recommends approval of REMICADE for PsA
Public Health - Method to measure radiation levels of building materials developed
Pulmonary Hypertension - HIV-related pulmonary hypertension reviewed
Rabies Vaccine - The use of rabies immune globulin by emergency physicians
Regulatory Issues - Cancer specialists propose new approval track for targeted drugs
Renal Cancer - Drugs that manage angiogenesis slow renal cell carcinoma progression
Renal Cell Carcinoma - EMEA grants orphan drug designation to BAY 43-9006
Restless Legs Syndrome - Study: Requip reduces periodic leg movements in patients with RLS
Salmonella Vaccine - Immune responses to killed Salmonella vaccine investigated
Salmonella Vaccine - Oral immunization with RfaH mutant protects mice against salmonellosis
Sexual and Reproductive Health - Survey reveals surprising insights into parental attitudes toward teen sex
Shigellosis Epidemiology - Shigellosis incidence high in Peruvian soldiers in Amazon River basin
Skin Infection - sNDA submitted for Merrem I.V. for complicated skin infections
Smallpox - FDA accepts BLA filing for Vaccinia Immune Globulin
Streptococcus Vaccine - Streptococcus pneumoniae epidemiology from Portugal aids vaccine choice
Stress Response - Chronic stress regulates neuroendocrine responses in laying hens
Survival & Mortality - Health care program lowers child and maternal mortality in Bangladesh
Tapeworm - Two antigens for Taenia solium tapeworm infection characterized
Tobacco Use - Exposure to cigarette smoke affects antibody responses to oxidized LDL
Tuberculosis - New blood test to detect TB infection not affected by BCG vaccination
Tuberculosis - TB infection interferon-gamma-based assay using new antigens developed
Tuberculosis Vaccine - Macrophage apoptosis in host immunity to mycobacterial infections reviewed
Tuberculosis Vaccine - T-cell epitopes on novel protective antigen of M. tuberculosis identified
Virology - A sequence essential for virus replication has been identified
Weight Loss - Organochlorine pollution affects weight loss in obese individuals
West Nile Virus - West Nile Virus introduced into Harris County, Texas, in 2002
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