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Antioxidants
Induction of metallothionein requires transcription factor and zinc
September 5th, 2004
The induction of metallothionein I by phenolic antioxidants requires metal-activated transcription factor 1 (MTF-1) and zinc. "Phenolic antioxidants, such as tBHQ [2,5-di-(t-butyl)-1,4-hydroquinone], induce Mt1 (metallothionein 1) gene expression and accumulation of MT protein. Induction of Mt1 mRNA does not depend on protein synthesis, and correlates with oxidation-reduction functions of the antioxidants. In the present study, we analyzed the biochemical pathway of the induction," scientists in the United States report. "Induction depends on the presence of MTF-1 (metal-activated transcription factor 1), a transcription factor that is required for...
Source: Medical Letter on the CDC & FDA (2004-09-05)
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