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HIV/AIDS Research
Noninfectious X4 but not R5 HIV-1 inhibits lymphoid tissue antibody response
September 5th, 2004
Noninfectious X4 but not R5 HIV-1 virions inhibit lymphoid tissue antibody response. According to recent research published in the Journal of Virology, "Ex vivo human immunodeficiency virus type 1 (HIV-1) infection of human lymphoid tissue recapitulates some aspects of in vivo HIV-1 infection, including a severe depletion of CD4+ T cells and suppression of humoral immune responses to recall antigens or to polyclonal stimuli. "These effects are induced by infection with X4 HIV-1 variants, whereas infection with R5 variants results in only mild depletion of CD4+ T cells and no suppression of immune responses." "To study the...
Source: Medical Letter on the CDC & FDA (2004-09-05)
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