AIDS/HIV Vaccine

Candidate HIV type 1 vaccines elicit long-term memory B-cell responses

Published in Medical Letter on the CDC and FDA, September 12th, 2004

Recipients of candidate human immunodeficiency virus type 1 vaccines exhibit long-term memory B-cell responses.

"The efficacy and practical application of human immunodeficiency virus type I (HIV-1) vaccines may depend in part on the longevity of the immune responses generated, particularly those in the memory compartment. Candidate vaccines based on the HIV-1 envelope glycoproteins generate binding and neutralizing antibodies in humans but there have been no prior studies on the long-term persistence and recall of those responses. We evaluated six healthy, HIV non-infected adults who had received a combination of recombinant canarypox HIV-1 vaccines boosted by gp120...

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Source: Medical Letter on the CDC and FDA (2004-09-12)

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