Hepatitis E Diagnosis

ELISA for hepatitis E detects antibodies to genotypes 1, 2, 3, and 4

Published in Medical Letter on the CDC and FDA, September 12th, 2004

An ELISA for putative neutralizing antibodies to hepatitis E virus detects antibodies to genotypes 1, 2, 3, and 4.

"Two monoclonal antibodies that neutralize hepatitis E virus (HEV) were used to identify a subregion of ORF2 capsid protein spanning amino acids 459-607 as the shortest peptide to form the corresponding neutralization epitopes. An enzyme-linked immunosorbent assay (ELISA) based on a purified recombinant protein covering amino acids 458-607 in ORF2 of the Sar-55 strain (genotype 1) efficiently detected anti-HEV in non-human primates that had been experimentally infected with the four known mammalian genotypes of HEV, respectively. However, anti-HEV in these...

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Source: Medical Letter on the CDC and FDA (2004-09-12)

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