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Tuberculosis Therapy

Multidrug-resistant tuberculosis treated successfully after liver transplant

Published in Medical Letter on the CDC and FDA, September 26th, 2004

Researchers report the successful treatment of multidrug-resistant tuberculosis following drug-induced hepatic necrosis requiring liver transplant.

"A 28-year-old female developed multidrug-resistant (MDR) tuberculosis lymphadenitis following a trip to India. She was initially treated with a four-drug regimen of first-line anti-tuberculosis medications, but when sensitivities indicated resistance to isoniazid and rifampin, her regimen was altered to ciprofloxacin (CFX), pyrazinamide (PZA), and ethambutol. She subsequently developed a rash, flu-like symptoms, and fever, which progressed to acute hepatic necrosis despite discontinuation of medication," researchers in...

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