Developmental Biology
Mutant mice provide evidence for function of lamin B1 in mammalian development
Published in Medical Letter on the CDC and FDA, September 26th, 2004
According to recent research from the United States, "Lamins are key structural components of the nuclear lamina, an intermediate filament meshwork that lies beneath the inner nuclear membrane. Lamins play a role in nuclear architecture, DNA replication, and gene expression.
"Mutations affecting A-type lamins have been associated with a variety of human diseases, including muscular dystrophy, cardiomyopathy, lipodystrophy, and progeria, but mutations in B-type lamins have never been identified in humans or in experimental animals."
L. Vergnes and colleagues of the...
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