Immunology
Peripheral CD4+CD8+ T cells participate in adaptive immunity
Published in Medical Letter on the CDC and FDA, September 26th, 2004
According to published research from the United States, "although an increased frequency of CD4+CD8+ T cells has been observed in the peripheral blood during viral infections, their role, function, and biologic significance are still poorly understood. Here we demonstrate that the circulating CD4+CD8+ T-cell population contains mature effector memory lymphocytes specific for antigens of multiple past, latent, and high-level persistent viral infections."
"Upon in vitro antigenic challenge, a higher frequency of CD4+CD8+ than single-positive cells displayed a T helper 1/T cytotoxic 1...
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