Susan Hasty, Publisher
Table of Contents . . . October 3rd, 2004
Non-Subscriber - Summaries OnlyRelated Areas: Other Issues in Medical Letter on the CDC and FDA | Other Publications
Angiology - Effects of vascular graft compliance mismatch on protein transport reported
Anthrax - U.S. FDA approves ciprofloxacin to manage postexposure inhalational anthrax
Malaria Transmission - Anopheles quadrimaculatus distribution and role in malaria reported
Tick-Borne Disease - Method for longitudinally sampling individual Ixodes ticks developed
Vaccine Safety - Fever after immunization reviewed
AIDS/HIV Vaccine - SIVmac Gag p27 capsid protein gene expression in potato reported
Acne - NDA submitted to FDA for acne product
Adverse Drug Events - Erythromycin combined with common drugs may increase cardiac death risk
Age-Related Macular Degeneration - FDA advisory committee reviews Macugen data
Allergy Medicine - FDA approves Clarinex syrup for allergies and hives in children
Anthrax - Anthrax risk from contact with infected livestock increased by hand cuts
Asthma - "Planned-care method" of asthma care reduces kids' symptoms
Asthma - Customized program reduces asthma symptoms in inner-city children
Asthma - Reducing allergens in the home helps inner-city children with asthma
Bipolar Disorder - Newer anticonvulsants for treating bipolar disorder reviewed
Botulism - Symptoms predictive of death in patients with food-borne botulism reported
Bovine Spongiform Encephelopathy - Japanese panel recommends dropping testing of younger cows for mad cow disease
Business Update - Biotech company business update includes vaccine development, financing, growth
Business Update - Technology upgrade cuts costs, improves earnings for China-based company
Business Update - Utah company discloses recent U.S. sales activity and share repurchases
Cancer Risk Factor - Leucomalachite green is mutagenic in female Big Blue B6C3F1 mice
Cancer Risk Factor - Micronucleus test used on epithelial cells from oral cavity of beedi smokers
Cardiac Arrest - FDA approves Sprint Fidelis defibrillation leads for sudden cardiac arrest
Cardiovascular Care - New labels can tout heart-healthy ingredient
Catheters - FDA clears new hydrophilic antimicrobial catheter for U.S. sales
Chemical Hazard - Study shows high levels of dioxin in New Zealand residents near chemical plant
Childhood Immunization - Dominican Republic immunization project announced
Complementary and Alternative Medicine - Expert warns of dangers of self-medicating with herbal medicines
Constipation - FDA approves Zelnorm as therapy for chronic constipation
Cryptosporidium - Host-adapted Cryptosporidium species in Canadian geese reported
Deep Vein Thrombosis - Agenix files ThromboView application for Canadian trials
Depression - Sex and drug use increase teen suicide risk
Depression - Suicide huge but preventable public health problem, says WHO
Dermatology - Dermatology drug market expected to grow 8% per year through 2008
Diagnostics - FDA grants expedited PMA review for LUMA Cervical Imaging System
Diet and Nutrition - Public health nutrition and food policy reviewed
Disease Management - Cancer survivors' other medical problems poorly managed
Drug Development - Japanese drug company launches urinary incontinence, frequency treatment in E.U.
Environmental Health - Biotech company settles with U.S. Justice over alleged Clean Air Act violations
Environmental Toxins - World Trade Center workers find high rates of respiratory, mental problems
Epidemiology - Korean-American women need education, access to cancer screening
Epidemiology - New report maps women's health in the United States
Epilepsy - Pharma company receives tentative approval for Gabapentin capsules
Fabry Disease - Enzyme replacement therapy for Fabry disease reviewed
HIV/AIDS - HIV vaccine progresses towards next phase
HIV/AIDS Healthcare - Model estimates resource needs for global HIV/AIDS healthcare services to 2007
HIV/AIDS Healthcare - Rapid-feedback model improves retention rate of HIV/AIDS healthcare intervention
HIV/AIDS Therapy - Optimization of antiretroviral resources is necessary to provide better access
HIV/AIDS Therapy - UNAIDS Drug Access Initiative evaluated in Chile
Healthcare & Politics - Promises of big spending on health dominate election campaign in Australia
Healthcare Coverage - Children with special health needs not getting consistent care
Healthcare Coverage - Guidant applauds proposed coverage of carotid artery stenting
Hepatitis - Application filed to market Pegasys for hepatitis and AIDS coinfection
Hepatitis B Vaccine - Dendritic cell vaccine for hepatitis B infection therapy is promising
Hepatitis B Vaccine - Hepatitis vaccine nonresponse linked to impaired lymphocyte activation
Hepatitis B Virus - Structure of glycans in hepatitis B virus surface proteins determined
Herpesvirus - HSV-2 EIAs vary in sensitivity/specificity of sub-Saharan African samples
Herpesvirus Vaccine - HSV-1 vaccine prevents clinical changes of HSV-1 encephalitis
Human Growth Hormone - FDA defers decision on Omnitrope application
Infectious Disease - $18 million bioinformatics center to become weapon against deadly diseases
Influenza - Antiviral medication Tamiflu to play role in pandemic flu preparedness
Influenza - Number of flu-associated hospitalizations on the rise, especially for elderly
Influenza - The doctors' view of flu vaccines for infants and toddlers
Information Technology - CDC invests $73 million to improve health information services for the public
Insulin - Exenatide new drug application accepted for review by the FDA
Irritable Bowel Syndrome - Cilansetron NDA granted priority review for IBS with diarrhea predominance
Legal Issues - Agency gets guilty pleas
Legal Issues - Biopharmaceutical company updates enzyme-related U.S. patent litigation
Listeria - Listeria innocua strains with L. monocytogenes genes reported
Liver Cancer - FDA will allow trials for the use of ThermoDox with RFA for liver cancer
Lung Cancer - Lung carcinogenesis in hamsters is inhibited by green tea
Lyme Disease - Identifying tick genes could halt disease, bioterrorism threat
Macular Degeneration - Confidence in Visudyne's potential reiterated for macular degeneration
Malaria - Math model studies effect of environmental fluctuations on malignant malaria
Mammography - Company gets FDA clearance to add digital mammography to PACS
Medical Devices - Company gets additional U.S. FDA clearance for neonatal, pediatric nasal device
Medical Devices - German company gets U.S. patent for artificial heart insert method, device
Medical Devices - Little-known FDA labs push medical devices to their limits
Medical Devices - Lumbar treatment device manufacturer disagrees with FDA panel's recommendation
Medical Devices - Maker of implantable artificial heart seeks approval for commercial model
Medical Equipment - Diagnostic systems maker receives U.S. FDA clearance on antibacterial test label
Medical Imaging - Coronis 5MP Mammo technology receives FDA 510k approval
Medication Compliance - Many patients never tell doctors they underuse medications because of costs
Meningitis - Growing numbers of colleges vaccinating against deadly brain disease
Mental Health - U.N. says suicide preventable if authorities and individuals take precautions
Myeloma - Foundation receives million-dollar grant from CDC
Myocardial Infarction - Canadian regulatory clearance received for RAMP Cardiac Marker Tests
Nerve Healing - FDA issues 510(k) clearance for NeuraWrap Nerve Protector
Obesity Pathogenesis - IGF-I stimulates cell growth and lipogenesis during adipocyte differentiation
Obstetrics - Some pregnant women are prescribed unsafe drugs
Occupational Safety - Ventilation in bars, casinos doesn't control health risk for hospitality workers
Orthopedics - Tissue repair technology company receives bone graft substitute FDA clearance
Pacemakers - FDA approves advanced digital pacemaker
Pancreatic Cancer - FDA orphan drug designation granted for AGRO100 in pancreatic cancer
Parkinson Disease - FDA approves Parcopa orally dissolving tablets for Parkinson disease
Parkinson Disease - FDA grants final approval for Parcopa
Patents - Company announces termination of litigation with Novartis
Patient Education - Government web site too complicated for U.K. diabetes sufferers
Patient Safety - Government study finds nearly half a million medical device injuries a year
Personnel - Lynda Sutton named director and VP of regulatory affairs by biopharm company
Pneumocystis Infection - DHPS gene mutation found in P. jiroveci isolates from sulfonamide-naïve patients
Polio Vaccination - Inoculation teams deploy after end of polio-vaccine boycott
Prescription Drugs - Common antibiotic can trigger cardiac deaths when used with other drugs
Proteomics - Gas-phase fractionation by mass spectrometry can improve protein identification
Proteomics - Nucleotide exchange factor ECT2 regulates PKC xi activity
Psychotropic Drugs - FDA grants SPA for 2 pivotal phase III trials of CORLUX
Quality Assurance - Washington state hospitals volunteer for CMS quality improvement initiative
Regulatory Issues - FDA makes correction: Extina user fee goal date is November 26, 2004
Respiratory Medicine - Multitarget vaccine against respiratory infections may be possible
SARS - Simultaneous multigene DNA sequencing identifies SARS coronavirus
SARS Virus - Method to detect coronavirus nucleocapsid protein in SARS patients developed
Salmonella - Multidrug-resistant typhoid result of 1-2 clones with single resistant plasmid
Smallpox Vaccine - Virus B5R protein antibodies neutralize vaccinia immune globulin
Staphylococcus Aureus - Math model explains MRSA outbreaks and success/failure of control measures
Stents - FDA approves new stent system to help prevent stroke
Substance Abuse - Surrogate parenting may help undo damage of prenatal cocaine exposure
Tobacco Use - No ethnic differences observed in smoking topography or cardiovascular response
Transfusion Medicine - Fatalities caused by transfusion-related acute lung injury reviewed
Transplant Medicine - FDA issues approvable letter for Certican
Transplantation Medicine - Korean government regulations on cellular therapy outlined
Tuberculosis - Hierarchy of control technologies improve health care facility infection control
Tuberculosis Risk Factor - Tuberculosis associated with etanercept, a tumor necrosis factor inhibitor
Tuberculosis Vaccine - IL-4 expression increased in cells from contacts of M. tuberculosis
Varicella - Chicken pox vaccine saves money, protects whole population
Varicella-Zoster Virus - Three major genotypes of varicella-zoster virus identified
Vibrio - Diversity and dynamics of north Atlantic coastal Vibrio community reported
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