Hepatitis C Virus
Ovine atadenovirus induces strong T cell response against hepatitis C
Published in Medical Letter on the CDC and FDA, October 17th, 2004
According to recent research published in the journal Vaccine, "Ovine atadenovirus (OAdV) is a novel gene transfer vector with excellent in vivo gene transfer characteristics. In the present study, we have investigated the ability of an OAdV vector to mediate a T cell response to an antigen of the hepatitis C virus (HCV) in mice. Specifically, an expression cassette coding for non-structural protein 3 (NS3) of hepatitis C virus was inserted into the OAdV genome and the resulting recombinant virus (OAdV-ns3) was shown to propagate stably...
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