Susan Hasty, Publisher
Table of Contents . . . November 7th, 2004
Non-Subscriber - Summaries OnlyRelated Areas: Other Issues in Medical Letter on the CDC and FDA | Other Publications
Brain Cancer - N-ethyl-N-nitrosourea increases brain mutations in neonatal mice
HIV/AIDS Therapy - Critical reporting elements for quality of study methods reported
Pneumococcal Vaccine - Murine model of immunity induced by pneumococcal vaccine developed
Poliomyelitis - Change in polio vaccine policy eliminates cases of vaccine-associated polio
West Nile Fever - Clinicopathologic study of West Nile Virus encephalomyelitis reported
AIDS/HIV Diagnosis - HIV-1 superinfections assessed by autologous heteroduplex mobility
AIDS/HIV Epidemiology - Current state of HIV and AIDS in Sub-Saharan Africa reviewed
Abdominal Aortic Aneurysm - FDA approves medical device to treat AAA
Acinetobacter Baumannii - Multiresistant Acinetobacter baumannii outbreak occurred in surgical room
Addiction Medicine - U.S. HHS awards grants to treat co-occurring substance abuse/mental disorders
Adverse Drug Events - Study documents adverse events of pneumococcal vaccine in children
Allergy Medicine - Patient knowledge of allergy immunotherapy better than expected
Anthrax - Study of primary care doctors' response to 2001 attacks shows prudent care
Arsenic Pollution - Synthetic zeolites used for arsenate removal from pollutant water
Arthritis - Pharmaceutical company offers its alternative to recalled arthritis medication
Avian Influenza Vaccine - Reassortant influenza vaccines control avian influenza
Awards - Biotech firm lauds Nobel winner, announces olfactory-based government contract
Bacterial Pathogen - Oligonucleotide array technology rapidly detects foodborne pathogenic bacteria
Bioterrorism - District of Columbia EHMSA licenses VisualDx diagnostic software
Bioterrorism - NIH grants awards for the development of human antibody against anthrax
Bipolar Disorder - FDA approves ABILIFY for acute bipolar mania, including manic and mixed episodes
Business Update - Agreement signed for distribution of bacterial detection system in Japan
Business Update - University study affirms efficacy of pheromone-based products, company says
Cancer Research - Companies announce filing of MAA in Europe to inject anticancer drug for MDS
Cancer Screening - DOD awards sole-source contract for the ThinPrep Pap Test
Cancer Therapy - Compounds with MDR1-enhanced anticancer activity identified
Cancer Therapy - Protein biomarkers and drug design for cancer treatments reviewed
Cardiac Monitors - FDA approves marketing a newly developed cardiac monitor
Cardiology - After initial damage, protective mechanisms within the heart were initiated
Cervical Cancer - Infection site and patient ethnicity affect HPV-induced cancer pathways
Cervical Cancer - Socioeconomic disparities affect disease incidence and mortality in U.S.
Childhood Obesity - Prevalence of overweight and obesity among Kuwaiti adolescents reported
Clinical Trials - Clinical investigators review, endorse phase 2 trials for deep vein therapy
Clinical Trials - Company expands consulting services to full service clinical trials
Clinical Trials - Drug improves Huntington disease movement disorder in clinical trial
Cochlear Implant - Bionics cochlear auditory implants recalled worldwide
Cognitive Function - Decision-making brains weigh up evidence
Conjunctivitis Outbreak - E-mail surveys assist investigation and response in conjunctivitis outbreak
Cystic Fibrosis - Company announces final research report on cystic fibrosis treatment
Cystic Fibrosis - Foundation urges newborn screening for CF in test panels
Dental Caries - HIV infection increases risk of dental caries in children
Dermatology - FDA issues 510(k) clearance for Varilite dual wavelength laser
Diabetes Prevention - Researchers study sixth-graders to prevent type 2 diabetes
Diabetes Therapy - FDA approval granted for Metformin Hydrochloride 500 mg
Diagnostics - U.S. NIH grant to fund human asthma testing with Breathmeter
Drug Delivery - U.S. FDA approves new and easy way to take ENBREL
Drug Development - Pharmaceutical receives U.S. FDA approval of GI disease and hepatitis drugs
Drug Development - Study results of treatment for leukemia with arsenic trioxide presented
Drug Development - U.S. FDA grants orphan status to drug for treatment of soft tissue sarcoma
Emerging Pathogens - Emerging pathogen suggests amphibian trade should be closely monitored
Environmental Health - Diesel exhaust enhances expression of IL-13 in bronchial epithelium
Esophageal Cancer - Company announces clinical hold on TNFerade trials
Finance - Company raises $12 million to fund gene therapy
Finance - NIH funds first national SNP genotyping center
Food Safety - Food-borne illness strikes at least 2 billion people a year
Food-Borne Illness - Biogenic amines and bacteria analyzed in recalled canned anchovies
Generic Drugs - Pharma company recieves FDA approval for nicotine gum and ibuprofen suspension
Genomics - Comparative study of Legionnaire's disease published
Glaucoma - FDA gives final approval for Brimonidine Tartrate Ophthalmic Solution, 0.2% ANDA
Glioblastoma Multiforme - Protein patterns can be used to identify GBM subtypes
Glycopeptide-Resistant Enterococci - Debate-guidelines for glycopeptide-resistant enterococci control have not worked
HIV/AIDS Epidemiology - HIV-1 non-B subtypes from heterosexual transmission predominate in Scotland
HIV/AIDS Prevention - Primary hotline questions in Netherlands regard HIV transmission/risk/testing
HIV/AIDS Research - APOBEC3G incorporated into HIV-1 virions through viral/nonviral RNA interactions
HIV/AIDS Research - Host cell gene expression varies during HIV-1 latency or reactivation
HIV/AIDS Treatment - Study: Fuzeon plus active boosted PI doubles long-term response
Healthcare Access - New PAHO fact sheets on HIV reflect differences in cost, care, coverage
Heart Disease - Canadian biotech company begins two studies on cholesterol combination therapy
Heart Disease - Clinical trials slated for choelsterol drug
Hepatitis/HIV Coinfection - FDA grants priority review to Pegasys with Copegus for HCV in HIV patients
Hepatocellular Carcinoma - Gene expression patterns with prognostic value identified
Hodgkin's Disease - Drug receives orphan designation
Imaging - FDA extends review period for contrast agent MS-325 by 3 months
Imaging - Lung image database consortium established for medical imaging researchers
Immunology - IL-7 has dose-dependent effects on T-cell development
Infection Control - Disinfection, and sterilization adherence reduce hospital-related infections
Infectious Disease - Company awarded SIBR grant for infectious disease detection
Influenza - Drug-DNA combination could offer longer-lasting, more efficient flu vaccine
Influenza - Experts: Good hygiene can ward off flu
Influenza - Study to test flu shot and nasal spray flu vaccine side by side
Influenza - Survey of hospitals quantifies flu vaccine price gouging
Influenza - Thirty million doses of influenza vaccine shipped to healthcare providers
Influenza - U.S. CDC urges high-risk groups to get vaccinated, healthy people to wait
Influenza - U.S. funding granted for new influenza drug
Influenza - U.S. health services department releases statement regarding Chiron flu vaccine
Influenza Vaccine - Hospital visit prevention by influenza vaccine during pregnancy studied
Influenza Vaccine - Remaining flu shots directed to high-risk patients
Information Technology - Software designer receives NIH grant to develop nutrition education software
Legal Issues - Maker of skin lightening creams responds to TV statement on product dangers
Leptospirosis - Unique Leptospira strain isolated from patient with pulmonary hemorrhage
Listeria - Listeria monocytogenes tracked in cheese processing plants
Listeriosis - New biosensor rapidly detects deadly food-borne pathogen
Macular Degeneration - U.S. FDA gives fast-track status for antiangiogenic
Malaria Vaccine - Antibodies to P. vivax protein studied in malaria-exposed subjects
Malaria Vaccine - Incidence of severe malaria useful as endpoint for vaccine trials
Malaria Vaccine - Molecular analysis of antibody response to malaria sporozoite reported
Malaria Vaccine - Quantitative PCR used to test vaccines in human experimental malaria
Medical Devices - Company is awarded ISO certification for in vitro diagnostic medical devices
Medical Devices - Patent for stroke diagnostic device to measure protein biomarkers issued to SynX
Medicare - HHS seeks to expand Medicare coverage
Meningitis Outbreak - Nosocomial meningitis outbreak caused by Acinetobacter baumannii
Meningococcal Disease - Domestic clones of N. meningitidis circulated in meningococcal disease outbreak
Meningoencephalitis - Invasion of CNS by cryptococcal yeast cells characterized
Menopause - New campaign promotes benefits of hormone therapy
Menopause - Tentative approval granted for generic version of Femhrt tablets
Mental Health - APA applauds passage of Mentally Ill Offender Treatment and Crime Reduction Act
Metabolic Syndrome - Incidence of metabolic syndrome among Moroccan Sahraoui women reported
Multiple Myeloma - U.S. FDA grants Aplidin orphan drug status for the treatment of multiple myeloma
Obesity - Company wins phase I SBIR grant for obesity program
Obesity Surgery - Surgery effective for extremely obese Americans
Oncogenesis - Viruses, chemicals, and co-carcinogenesis reviewed
Oncology - FDA grants fast-track designation for metastatic melanoma treatment
Oncology - Phase II trial slated for renal cancer treatment
Opthalmology - Treatment for wet age-related macular degeneration receives new brand name
Osteoporosis - Study shows once-monthly Boniva increases bone density and reduces breakdown
Osteoporosis - U.S. Surgeon General: Immediate action needed to prevent osteoporotic fractures
Otitis Media - Nasopharyngeal pathogens in Danish children with otitis media studied
Patents - Periostat maker files patent infringement claim against IVAX, CorePharma
Pharmacology - P-glycoprotein rapidly regulated at the blood-brain barrier by endothelin-1
Poliomyelitis - Vaccine-caused cases of polio have been eliminated in the United States
Poxvirus Vaccine - Structural proteomics of the poxvirus family reviewed
Prion Disease - Yeast prions not involved in transcriptional activity
Professional Education - Cleveland consortium to share $14 million federal grant
Proteomics - Helical forms of peptides determined by NMR and molecular dynamics
Research Expertise - Strategies addressed to discourage brain drain of international scientists
SARS Infection Control - Providing SARS infection control information to outpatients increases compliance
SARS Vaccine - Antibody responses against SARS-coronavirus studied in SARS patients
Salmonella Outbreak - Salmonella outbreak traced to unshelled peanuts originating from one country
Sarcopenia - Impaired muscle protein synthesis linked to S6K1 dysregulation
Smallpox - FDA fast track status granted for modified vaccinia ankara program
Smallpox - U.S. HHS awards $232 million in biodefense contracts for vaccine development
Smallpox Research - California scientists help bring study of smallpox virus into 'molecular age'
Smallpox Vaccine - Positive side effects of smallpox vaccination described
Swine Fever Virus - Optimized protocol developed for detection of classical swine fever virus
Systemic Lupus Erythematosus - Preliminary results of Prestara trial on BMD in women with lupus not positive
T Cell Lymphoma - U.S. FDA grants Fast Track designation for FK228 in cutaneous T cell lymphoma
Tobacco Use - Smoking but not areca quid chewing increase micronuclei formation
Tuberculosis - M. tuberculosis antigen structures confirm binding orientation
Tuberculosis Vaccine - "M. tuberculosis-induced IFN-gamma expression lower in TB patients
Tuberculosis Vaccine - BCG heat-shock proteins protect against tuberculosis challenge
Tularemia - Genetic relations among Francisella tularensis isolates analyzed
Vaccines - Study finds demand for vaccines in U.S. will increase 8.6% annually
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