Pneumococcal Vaccine
Murine model of immunity induced by pneumococcal vaccine developed
Published in Medical Letter on the CDC and FDA, November 7th, 2004
According to recent research from the United States, "We developed a murine model for assessment of immunological memory and antibody-induced protection to nasopharyngeal (NP) challenges. BALB/c female mice (n=10 mice per study parameter) were immunized with two priming doses of the licensed 7-valent pneumococcal (Pnc) conjugate vaccine and immune responses [antibody immunoglobulin G (IgG) levels, avidity and opsonophagocytic activity] were monitored for 26 weeks until IgG levels decreased to nearly baseline. A booster dose of either 2 mcg conjugate...
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