Toxicology
Riddelliine produces cellular injury leading to hemangiosarcoma formation
Published in Medical Letter on the CDC and FDA, November 14th, 2004
According to recent research published in the journal Experimental and Toxicologic Pathology, "riddelliine alters hepatocellular and endothelial cell kinetics and function including stimulating an increase in hepatocytic vascular endothelial growth factor (VEGF) in the absence of increased serological levels of VEGF (NYSKA et al. 2002). The objective of this study was to further assess hepatic VEGF and KDR/flk-1 synthesis and expression by hepatic cells under riddelliine treatment conditions."
"Forty-two male F344/N rats were dosed by gavage with riddelliine (0, 1.0,...
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