Pertussis
Subassemblies of pertussis toxin subunits analyzed in vivo
Published in Medical Letter on the CDC and FDA, November 14th, 2004
According to published research from the United States, "Pertussis toxin (PT) has an AB5 structure that is typical of many bacterial protein toxins; however, this toxin is more complex than many toxins since it is composed of five different subunit types, subunits S1 to S5. Little is known about how PT assembles in vivo and how and when it interacts with its secretion apparatus, known as the Ptl transporter. In order to better understand these events, we expressed subsets of the genes encoding the S1, S2, and/or...
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