Susan Hasty, Publisher
Table of Contents . . . November 21st, 2004
Non-Subscriber - Summaries OnlyRelated Areas: Other Issues in Medical Letter on the CDC and FDA | Other Publications
Botulism - Food-borne botulism in the United States reviewed
Enterovirus - Enterovirus 68 shares biological features with enteroviruses and rhinoviruses
Food Safety - Antimicrobial resistance risk assessment in food safety reviewed
Interleukins - Mechanism of action of IL-13 antagonist in cells expressing IL-4R determined
Trichomoniasis - Dicationic compounds effective against Trichomonas vaginalis identified
AIDS/HIV Therapy - Pharmacokinetic properties of reverse transcriptase inhibitors reviewed
AIDS/HIV Vaccine - Kinetics of virus-specific CD8+ T cells in HIV infection determined
AIDS/HIV Vaccine - Vaccine against HIV-1 B and E subtypes is safe and immunogenic
Adenovirus - Genome of human adenovirus serotype 1 sequenced and annotated
Adrenergic Receptors - Haploptypes have varying influences on effects of alpha2C Del322-325 marker
Adverse Drug Effects - New systematic tools to monitor adverse event reporting developed
Aging - NIA establishes new demography centers for geriatrics research
Alzheimer Disease - U.S. FDA approves orally disintegrating tablet formulation of ARICEPT
Alzheimer Research - Drug developer, Georgetown University awarded grant to develop Alzheimer drug
Anal Fissure - Cellegesic granted priority review by U.S. FDA
Anthrax - Anthrax vaccine award rescheduled
Anthrax Vaccine - Polyol osmolytes prevent thermal inactivation of anthrax antigen
Antimicrobial Resistance - Antimicrobial resistance takes a large toll in developing countries
Arterial Injury - Nox2-mediated oxidant production has requisite role in response to tissue injury
Arthritis - Results from two REMICADE studies presented at conference
Avian Influenza - Thailand's 12th human death from bird flu
Biometrics - DoD awards contract to develop multimodal biometric systems
Botulism - Cangene identified as sole-source supplier for anti-botulism drug
Brain Cancer - Mice mutant for Nf1 and Trp53 model the dynamics of astrocytoma susceptibility
Business Update - Orthopedics company announces entry into U.S. ceramic hip market
Cancer Research - Experimental reovirus-based cancer therapy kills host cells, researchers find
Cancer Risk - Raw vegetable consumption decreases cancer risk
Cancer Screening - Breast and cervical cancer screenings are low among Mississippi Delta women
Cancer Screening - Racial differences, poverty linked to mammography use
Chikungunya Virus - Chikungunya virus epidemic reemerged in Democratic Republic of the Congo
Coronary Angioplasty - U.S. FDA grants clearance for new IQ Guide Wire
Cosmetic Surgery - U.S. FDA approves sale of self-anchoring contour threads for mid-face lifts
Dengue Virus - Dengue-2 genotype IV is the predominant and circulating strain in northern India
Depression - Company receives FDA approval for treatment-resistant depression treatment IDE
Diabetic Nephropathy - Body lead levels linked to kidney decline in diabetic patients
Dietary Supplements - Seville orange extracts may not be safe for weight loss
Drug Development - Application of pharmacogenetics to drug development reviewed
Drug Development - Cost-related approach for evaluating drug development programs outlined
Drug Development - Drug development software assists with regulatory path
Embolism - Blood-clot imaging technology gets U.S. FDA approval for phase 2 clinical trial
Employee Assistance Programs - Company awarded SAMHSA grant, partnership to explore services for young adults
Encephalitis Vaccine - Encephalomyelitis reported after tick-borne encephalitis vaccination
Escherichia Coli - Pathogen distribution model developed for E. coli O157:H7 in ground beef
Finance - Biopharmaceutical firm reports record operating performance
Finance - Pharmaceutical company announces third quarter performance, EPS of $0.60
Fitness - $1.3 million CDC grant will fund workplace physical activity intervention
Food Safety - Food recall system 'highly effective,' says NFPA in response to GAO report
Food Service Inspection - Adequate lighting necessary for proper inspection of food service operations
Food and Drug Administration - FDA agency actions and nature of congressional influence investigated
HIV/AIDS - Trial for HIV prevention gel commences
HIV/AIDS Coinfection - High HTLV-1 prevalence in immigrant male-to-female transsexual HIV+ sex workers
HIV/AIDS Pathogenesis - HIV-1 gp120 induces abnormal maturation of dendritic cells
HIV/AIDS Prevention - Condoms remain a stigma among healthcare workers in Rwanda
HIV/AIDS Prevention - Prevention program demonstrates change in HIV/AIDS/STI knowledge in Sierra Leone
HIV/AIDS Prevention - Spread of HIV could slow if repeat testing is supported
HIV/AIDS Risk Factor - HSV-2 is key risk factor in promoting HIV transmission
HIV/AIDS Screening - U.S. Health and Human Services, Ad Council launch HIV detection campaign
HIV/AIDS Therapy - FDA grants traditional approval for fusion inhibitor for HIV treatment
HIV/AIDS Therapy - HIV-inhibitory cyclic depsipeptide isolated from marine sponge
HIV/AIDS Transmission - Myths dispelled concerning HIV transmission among conflict-affected populations
HIV/AIDS Vertical Transmission - HIV subtype C preferentially transmitted in utero over subtypes A or D
Healthcare Planning - Surge healthcare planning necessary for future epidemic and terrorist attacks
Hepatitis C Virus - Persistence of hepatitis C infection linked to low levels of heterogeneity
Hypertension - Studies examine risk factors associated with prehypertension
Immunology - MHC molecule has marginal effects on survival of intraepithelial lymphocytes
Immunology - Recombinant IL-7 induces proliferation of naive macaque T cells in vivo
Infectious Diseases - Institute to enhance health professional training in sub-Saharan Africa
Infectious Diseases - Malaria, TB, AIDS impose high economic burden in developing country households
Influenza - Most people can skip flu vaccine
Influenza - Safety trials for flu vaccines nasal technology to be complete early next year
Influenza - Tamiflu cited in new antiviral guidelines for preventing, treating influenza
Influenza - Vaccine production relies on quaint system
Influenza Virus - Influenza increases winter mortality in the United States
Intracranial Hypertension - Tretinoin, acitretin, and etretinate linked to intracranial hypertension
Kidney Disease - Worldwide approach tackles kidney disease
Leishmaniasis - Leishmania paradigm of pathogenesis and protection reviewed
Leishmaniasis Vaccine - Development of effector and memory T cells in leishmaniasis reviewed
Leukemia - Campath approved for marketing in new single-use vial
Liposuction - U.S. FDA approves use of laser during liposuction
Lung Cancer - Occupational exposure to acrylonitririle increases risk of lung cancer
Lupus - FDA indicates Riquent is approvable, requires completion of additional study
Malaria - Study shows Corixa's MPL adjuvant protected against uncomplicated malaria
Malaria Transmission - Antibodies immobilize Plasmodium sporozoites injected by mosquitoes
Malaria Vaccine - Challenges to developing vaccine to malaria parasites reviewed
Malaria Vaccine - Information on mixed Plasmodium infections aids vaccine development
Malaria Vaccine - Multiple infections needed to acquire immunity to malaria
Maternal Blood - Pregnant woman in Russia have elevated blood levels of organic pollutants
Measles Vaccine - CD46 level not altered in measles virus vaccine strain-infected cells
Measles Vaccine - Measles has re-emerged among young adults in Marseilles, France
Medical Error - World Health Organization targets medical mistakes
Meningococcal Disease - Neisseria meningitides sequence type 66 identified in Poland
Mental Health - Child psychiatrist comments on FDA warning labels for pediatric antidepressants
Mosquito-Borne Disease - Male insecticide resistance and mosquito transgene dispersal discussed
Multiple Myeloma - Research foundation awards 3-year grant to study molecular multiple myeloma
Multiple Sclerosis - Novel approaches and cutting edge immunotherapies in multiple sclerosis
Mutation - Disease-causing RyR2 mutations enhance RyR2 luminal CA2+ activation
Nematode Infection - IL-4-producing T cells during intestinal nematode infections reviewed
Neurology - New drug application submitted for insomnia treatment
Neuroscience - Effect of PEDF on cerebellar granule cell gene expression determined
Nicotine Addiction - Speaking English may be hazardous to your health
Noscomial Pathogens - Incidence of noscomial pathogens determined for 38 centers from 17 countries
Nutrition - Encouraging consumer use of food label information needs innovative approaches
Obesity Epidemiology - Americans slightly taller, much heavier than 40 years ago
Obstetrics - Antiretroviral Pregnancy Registry monitoring and analysis plan described
Obstructive Sleep Apnea - FDA clears ARES for in-home diagnosis of obstructive sleep apnea
Occupational Health - Dose/age associated with translocation frequency in low-dose radiation exposure
Oncology - U.S. FDA accepts response to approvable letter for Combidex
Optometry - U.S. FDA warned consumers against using decorative contact lenses
Orthopedics - U.S. FDA clears orthopedic therapy laser devices
Ovarian Cancer - Early ovarian cancer plus tuberculosis mimics advanced ovarian cancer
Ovarian Cancer - Generic equivalent to Paraplatin launched
Pediatrics - Relations between child health and household tobacco and alcohol use studied
Personnel - Clinical trials development company appoints new leadership
Pertussis - Whooping cough reemerges, hits adolescents hard in U.S., puts infants at risk
Piroplasmosis - Theileria orientalis piroplasm protein characterized
Plastic Surgery - Injectable wrinkle filler material found safe and effective
Pneumonia - Nursing home-acquired pneumonia differs from hospital/community-acquired
Public Health - Cities at risk are lacking municipal heat wave response plans
Public Health - Report: Hispanics face more health risks
RNA Research - University of Delaware awarded grant to study small RNA molecules in plants
Rheumatoid Arthritis - Healthcare information company measures number of users for specific treatment
Rift Valley Fever Virus - Rift Valley fever virus protein blocks interferon production
Risk Assessment - Methods to manage risk assessments within risk analysis framework proposed
SARS - China orders local officials to take steps to prevent new SARS outbreak
SARS - Company publishes report on Chinese governments and the lesson of SARS
SARS - Hong Kong SARS patients suffered mental disorders
SARS Coronavirus - Medical geography of SARS is explored
Sexual & Reproductive Health - FDA approves Luveris for concomitant use with Gonal-f
Sexually Transmitted Disease - Screening rates for chlamydia among young U.S. women remain low
Skin Cancer - Skin cancer mortality rates declining in Europe
Skin Regeneration - Terminally sterile dermal regeneration template receives FDA approval, CE Mark
Smallpox Vaccine - Stevens-Johnson syndrome after smallpox vaccination reported
Staphylococcus Infection - Laboratory exposures to staphylococcal enterotoxin B reviewed
Stem Cell Research - Liver-derived stem cell differentiation results in TNF alpha-mediated apoptosis
Streptococcus - PCR assays examined for specificity in identifying Streptococcus pneumoniae
Sudden Infant Death Syndrome - Antibodies to staphylococcal toxins implicated in SIDS
Sudden Infant Death Syndrome - Mucosal immunity in first year related to sudden infant death syndrome
Toxoplasmosis - Toxoplasma heat shock protein stimulates dendritic cell maturation
Tuberculosis - Prevalence of tuberculosis in foreign-born patients in U.S. increasing
Tuberculosis - Tuberculosis presenting as endobronchial tumor reported
Tuberculosis Therapy - Group calls for new treatments for TB
Tuberculosis Vaccine - Potential public health impact of new tuberculosis vaccines discussed
Vaccine Development - Agreement announced for PER.C6 technology for foot-and-mouth disease vaccines
Veterinary Drug Development - U.S. FDA approves endotoxemia anti-inflammatory for dairy cattle
Virology - Drugmaker and USAMRIID to study ATryn for viral hemorrhagic diseases
West Nile Virus - Current status of West Nile virus reviewed
West Nile Virus - West Nile virus has crossed geographical boundaries
Yellow Fever Vaccine - Divergence and dispersal of yellow fever virus in Brazil described
Yellow Fever Vaccine - Substitution in yellow fever-dengue virus protein reduces viremia
Yellow Fever Virus - Genetic relationships of yellow fever virus group investigated
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