Published in Medical Letter on the CDC and FDA, November 21st, 2004
According to recent research published in the Journal of Virology, "A chimeric yellow fever-dengue 1 (ChimeriVax-DEN1) virus was produced by the transfection of Vero cells with chimeric in vitro RNA transcripts. The cell culture supernatant was subjected to plaque purification for the identification of a vaccine candidate without mutations. Of 10 plaque-purified clones, one containing no mutation (clone J) was selected for production of the vaccine virus."
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