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AIDS/HIV Therapy

Pharmacokinetic properties of reverse transcriptase inhibitors reviewed

Published in Medical Letter on the CDC and FDA, November 21st, 2004

A researcher reviews the pharmacokinetic properties of nucleoside/nucleotide reverse transcriptase inhibitors in a recent issue of the Journal of Acquired Immune Deficiency Syndromes.

"Options for antiretroviral therapy in patients infected with HIV continue to expand as new drugs are integrated into treatment regimens. Nonetheless, nucleoside/nucleotide reverse transcriptase inhibitors (NRTIs/NtRTIs) remain the backbone of highly active antiretroviral therapy (HAART). With the approval of emtricitabine in 2003, there are now eight Food and Drug Administration (FDA)-approved NRTIs/NtRTIs," researchers in the United States report.

"Several of...

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