Sepsis
Active hemoglobin enhances LPS-induced injury to endothelial cells
Published in Medical Letter on the CDC and FDA, November 28th, 2004
According to a study from the United States, "The interaction of cell-free hemoglobin with lipopolysaccharide (LPS) is thought to aggravate the pathophysiology of sepsis and/or septic shock. This study examines the possible modulatory role of cell-free hemoglobin on LPS-induced apoptosis of cultured bovine aortic endothelial cells. Experiments were performed with or without fetal bovine serum, a source of LPS-binding protein and soluble CD14. In the absence of serum, LPS alone or co-incubated with purified bovine hemoglobin (BvHb), human hemoglobin (Hb), or...
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