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Anthrax Vaccine

Anthrax protective antigen predictive of serum anti-toxin activity

Published in Medical Letter on the CDC and FDA, November 28th, 2004

Bacillus anthracis protective antigen is predictive of serum anti-toxin activity in patients with bioterrorism-related cutaneous or inhalation anthrax.

According to recent research from the United States, "Anti-protective antigen (PA) immunoglobulin (Ig) G, toxin neutralization, and PA-specific IgG memory B cell responses were studied in patients with bioterrorism-related cutaneous or inhalation anthrax and in a patient with laboratory-acquired cutaneous anthrax. Responses were determined for >1 year after the onset of symptoms. Eleven days after the onset of symptoms (15 days after likely exposure), anti-PA IgG was detected in 16 of 17 patients with confirmed...

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